Animal models of choroidal and retinal neovascularization

Mechanisms of retinal and choroidal neovascularization.

Experimental Animal Models for Retinal and Choroidal Diseases

Experimental animal models have an important place in medical research for the development of new therapeutic strategies in the treatment of the ocular diseases in humans. The aim of using animal models in ocular experiments is to achieve the easiness in the understanding of the pathophysiology of the diseases and to determine the specific treatment protocols for the diseases. Currently, a numb...

Intravitreal infliximab and choroidal neovascularization in an animal model.

OBJECTIVE To determine whether intravitreal infliximab can inhibit the growth of choroidal neovascularization (CNV) in an animal model of age-related macular degeneration. METHODS Twenty-four brown Norway rats received 6 argon laser lesions of sufficient power to rupture the Bruch membrane in each eye. The right eye received a single intravitreal infliximab injection of 0.15 mg/mL, 1.5 mg/mL,...

Systemic rapamycin inhibits retinal and choroidal neovascularization in mice.

PURPOSE Rapamycin exhibits significant antitumor/antiangiogenic activity that is coupled with a decrease in vascular endothelial growth factor (VEGF) production and a reduction in the response of vascular endothelial cells to stimulation by VEGF. VEGF plays a significant role in neovascular pathologies of the eye, thus we tested the possibility of using rapamycin to inhibit retinal and choroida...

Prevalence of outer retinal tubulation in eyes with choroidal neovascularization

BACKGROUND Outer retinal tubulations (ORTs) are branching tubular structures located in the outer nuclear layer of the retina. The goal of this study is to determine the prevalence of ORTs observed in eyes with choroidal neovascularization (CNV) undergoing treatment with anti-angiogenic intravitreous injection (IVI) with anti-VEGF (vascular endothelial growth factor) at the Ophthalmology Depart...